Bus from Esteli to Granada
I just did this one. 4 hours and a very limiting schedule. I left cotran norte on the 2 pm expresso (yellow school bus) to Masaya. 2 hours to Tipitapa and another to the Masaya Bus terminal empty lot. Caught ordinario bus to Granada about 15 minutes later, and made it to Granada before dark. Not bad timing, but later in the day when I really like to travel. Bus attendant on Masaya bus didn{t know or didn{t want to tell me where I could get off on the highway on the outskirts of Masaya to flag down a Granada micro bus to save the time of going into Masaya, altho this always has the risk that the microbus might not stop if it were overloaded.
Coming back to Esteli, it gets worse: the return bus leaves Masaya at something like 645 am, too early for me. Going back I{ll catch a micro bus to La UCA, a cab to Mayoreo, and the Usual expresso (probably a nice new Marco Polo) back to Esteli. Other than the cost of the cab, this is probably the easier route. Time wise it should clock out to the same 4 hours, depending on how long I have to wait for the expresso, usually no more than 1 hour because you can also take the Ocotal and Somoto buses which will leave you at Shell Esquipulas.
There is at least one later bus from Esteli to Masaya, but that puts you in Granada even later.

You would
make it to Granada Faster if,you take the expreso Esteli-Managua all the way to Cotran Managua and catch a bus directly to Granada, you may even be lucky and catch the expresso Managua-Granada,just food for thought :-)
and the answer is . . .
anywhere . . . on the Managua/Masaya highway anywhere on the right side of the road is the place to be. School buses/ Mercedes new fleet buses and microvans will all be waiting for your gesture to get to Granada. Between the three kinds of transit, there's a bus every ten minutes.
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. . . Bus attendant on Masaya bus didn't know or didn't want to tell me where I could get off on the highway on the outskirts of Masaya to flag down a Granada micro bus to save the time of going into Masaya, altho this always has the risk that the microbus might not stop if it were overloaded.
microbus might not stop if it were overloaded.
I wouldn't worry to much about that.
...Thanks for the itinerary.
I will try it in reverse one of the days....